Planning

Wednesday, November 20, 2013

Time Event  
13:00 - 14:00 Welcome in Toulouse Mercure Hotel - Badges and abstract books delivery.  
14:00 - 14:15 Welcom address - Welcome  
14:15 - 14:35 Role of DNA polymerase eta in somatic hypermutation - Fumio Hanaoka  
14:35 - 14:55 Novel functions of the so-called “TLS” DNA polymerases DNA polymerases for the regulation of the replication program in human cells - Christophe Cazaux  
14:55 - 15:15 Impact of replication stress on S-phase checkpoint and common fragile site instability - Michèle Debatisse  
15:15 - 15:35 Low-dose stress responses - Fuyuki Ishikawa  
15:35 - 16:00 Role of TRF2 in oncogenesis - Eric Gilson  
16:00 - 16:30 Coffee break  
16:30 - 16:50 DNA replication: from origins to DNA damage and cell identity - Marcel Méchali  
16:50 - 17:10 Telomere length influences cancer cell differentiation in vivo - Hiroyuki Seimiya  
17:10 - 17:30 Repair of the shortest telomeres delays replicative senescence - Vincent Géli  
17:30 - 17:50 Integrated genomic analysis of hepatocellular carcinoma - Hiroyuki Aburatani  
17:50 - 18:10 Transcription/replication interference as a source of genomic instability and cancer - Philippe Pasero  
18:10 - 18:25 Tissue specific replication defects and their different outcome in MCM8 and MCM9 knock out mice - Malik Lutzmann (short talk 1)  
19:30 - 21:30 Dinner  

Thursday, November 21, 2013

Time Event  
08:30 - 08:50 ASXL1 mutations induce an MSD-like disease in mice via derepression of HoxA9 and miR125a - Toshio Kitamura  
08:50 - 09:10 The H3.3 histone chaperone HIRA primes chromatin for transcription recovery after DNA damage - Geneviève Almouzni  
09:10 - 09:30 Genomic imprinting in mammals: ‘imprinting control regions’ mediate mono-allelic expression at endogenous and ectopic gene loci - Robert Feil  
09:30 - 09:50 Ubiquitylation/deubiquitylation circuit of histone H3 at K23 couples maintenance DNA methylation with DNA - Makoto Nakanishi  
09:50 - 10:10 A small molecule, agonist of aldosterone, sensitizes cancer cells to platinum derived treatment through the degradation of the XPB helicase of TFIIH - Frédéric Coin  
10:15 - 10:45 Coffee break  
10:45 - 11:05 When splicing meets splicing - Annick Harel-Bellan  
11:05 - 11:25 Polycomb proteins in Drosophila development and cancer - Giacomo Cavalli  
11:25 - 11:45 Breast cancer risks in germline BRCA1 mutations carrier women - Jean Feunteun  
11:45 - 12:00 Molecular links between microenvironmental signals and epigenetic reprogramming processes via long non-coding RNA in glioblastoma - Yutaka Kondo (short talk 2)  
12:00 - 12:15 Tumor Suppressor FOXP3 Orchestrates H4K16ac and H3K4me3 for Target Gene Activation in Breast Cancer Cells - Hiroto Katoh (short talk 3)  
12:30 - 13:45 Lunch  
14:00 - 14:20 What is the Warburg effect ? Next-generation proteomics uncovers the secret of cancer. - Keiichi Nakayama  
14:20 - 14:40 Characterization of a Mink1-Prickle pathway implicated in cancer cell migration - Avais Daulat  
14:40 - 15:00 Coordinated Controls of checkpoints and metabolism by the transcription factor E4F1: Toward novel synthetic lethal approaches to cancer vulnerabilities? - Claude Sardet  
15:00 - 15:15 Hypoxia and nutrient starvation induce tumor aggressiveness - Tsuyoshi Osawa (short talk 4)  
15:15 - 15:30 Elucidation of the roles of membrane lipids in the progression of epithelial-mesenchymal transition - Junichi Ikenouchi (short talk 5)  
15:30 - 16:00 Coffee break  
16:00 - 16:20 Molecular mechanisms of osteoclastogenic signal - Jun-Ichiro Inoue  
16:20 - 16:40 Study of mechanical stress and tumor cell proliferation in multi-cellular tumor spheroid - Valérie Lobjois  
16:40 - 17:00 Loss of E-cadherin in the liver leads to sclerosing cholangitis and promotes tumorigenesis in mice - Shin Maeda  
17:00 - 17:20 Cyclin A2: a novel player in cell-cell and cell-niche interactions - Jean-Marie Blanchard  
17:20 - 17:40 Cullin3 E3 ubiquitin ligase-based angiogenic regulation - Shigeki Higahsiyama  
17:40 - 17:55 Biochemical and biophysical analysis for the H. pylori CagA-SHP2 oncoprotein interaction - Takeru Hayashi (short talk 6)  
18:30 - 19:30 Reception by the Mayor of Toulouse - Salles des Illustres - Capitole - Salles des Illustres - Capitole  
19:30 - 21:00 A guided walk in Toulouse by night - A walk in Toulouse  
21:00 - 23:00 Dinner  

Friday, November 22, 2013

Time Event  
08:30 - 08:50 HTLV-1 bZIP factor determines cell tropism - Masao Matsuoka  
08:50 - 09:10 Cell polarity, cell signaling and cancer - Jean-Paul Borg  
09:10 - 09:30 Mechanisms determining subcellular localization of the oncogenic protein tyosinase phosphatase SHP2 - Masanori Hatakeyama  
09:30 - 09:45 TTF-1/NKX2-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma - Tomoya Yamaguchi (short talk 7)  
09:45 - 10:00 Novel functions of Wnt signaling pathways in mitotic progression. - Koji Kikuchi (short talk 8)  
10:00 - 10:30 Coffee break  
10:30 - 10:50 Mechanisms of development in childhood cancers, translational perspectives - Olivier Delatre  
10:50 - 11:05 Oncogenic role of the retina-specific transcription factor NRL in metastatic medulloblastoma - Célio Pouponnot (short talk 9)  
11:05 - 11:25 Specific roles for BRAF and CRAF in NRAS-induced mouse melanoma - Alain Eychène  
11:25 - 11:40 Contribution of Keap1-Nrf2 pathway to metabolic reprogramming and cell proliferation - Hozumi Motohashi (short talk 10)  
12:00 - 13:30 Lunch  
14:00 - 20:00 Oncopole tour, Carcassonne medieval city…and red wine ! - Oncopole tour, Carcassonne medieval city…and red wine !  
21:00 - 23:00 Dinner  

Saturday, November 23, 2013

Time Event  
08:30 - 08:50 CD44s-xCT axis is a therapeutic target for cancer stem cells - Hideyuki Saya  
08:50 - 09:10 Function of thrombopoietin receptor (MPL) mutations in hematological myeloid malignancies - William Vainchenker or Isabelle Plo  
09:10 - 09:30 The calcineurin/NFAT pathway in leukemia and breast cancer models - Christine Tran Quang  
09:30 - 09:50 Genetic analysis of Down Syndrome-related myeloid neoplasms - Seishi Ogawa  
09:50 - 10:10 Tumor HEVs: specialized blood vessels which contribute to the fight against cancer - Jean-Philippe Girard  
10:15 - 10:45 Coffee break  
10:45 - 11:05 Leukemic gene network: from genetic interaction to in vivo function - Takuro Nakamura  
11:05 - 11:25 Activation of distinct oncogenic signaling pathways in human mammary epithelial cells results in fully different cascades of genetic and epigenetic modifications - Charles Theillet  
11:25 - 11:40 Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence - Shoichiro Takeishi (short talk 11)  
11:40 - 12:00 Small nucleolar RNAs and long non coding RNAs: new players in hematological cancers - Pierre Brousset  
12:00 - 12:20 PML, an essential contributor of APL response to targeted therapies - Hugues de Thé  
12:30 - 13:00 Conclusions - End of meeting - End talk  
  
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