Programme

Semaine Mer. 20 Jeu. 21 Ven. 22 Sam. 23 Liste

	Mer. 20	Jeu. 21	Ven. 22	Sam. 23
08:00 09:00 10:00 11:00 12:00 13:00 14:00 15:00 16:00 17:00 18:00 19:00 20:00 21:00 22:00 23:00	Accueil à l'Hôtel Mercure 13:00 - 14:00 (1h) Accueil à l'Hôtel Mercure Distribution des badges et des livres des abstracts. Discours de bienvenue 14:00 - 14:15 (15min) Discours de bienvenue Bienvenue Role of DNA polymerase eta in somatic hypermutation 14:15 - 14:35 (20min) Role of DNA polymerase eta in somatic hypermutation Fumio Hanaoka Novel functions of the so-called “TLS” DNA polymerases DNA polymerases for the regulation of the replication program in human cells 14:35 - 14:55 (20min) Novel functions of the so-called “TLS” DNA polymerases DNA polymerases for the regulation of the replication program in human cells Christophe Cazaux Impact of replication stress on S-phase checkpoint and common fragile site instability 14:55 - 15:15 (20min) Impact of replication stress on S-phase checkpoint and common fragile site instability Michèle Debatisse Low-dose stress responses 15:15 - 15:35 (20min) Low-dose stress responses Fuyuki Ishikawa Role of TRF2 in oncogenesis 15:35 - 16:00 (25min) Role of TRF2 in oncogenesis Eric Gilson Pause café 16:00 - 16:30 (30min) Pause café DNA replication: from origins to DNA damage and cell identity 16:30 - 16:50 (20min) DNA replication: from origins to DNA damage and cell identity Marcel Méchali Telomere length influences cancer cell differentiation in vivo 16:50 - 17:10 (20min) Telomere length influences cancer cell differentiation in vivo Hiroyuki Seimiya Repair of the shortest telomeres delays replicative senescence 17:10 - 17:30 (20min) Repair of the shortest telomeres delays replicative senescence Vincent Géli Integrated genomic analysis of hepatocellular carcinoma 17:30 - 17:50 (20min) Integrated genomic analysis of hepatocellular carcinoma Hiroyuki Aburatani Transcription/replication interference as a source of genomic instability and cancer 17:50 - 18:10 (20min) Transcription/replication interference as a source of genomic instability and cancer Philippe Pasero Tissue specific replication defects and their different outcome in MCM8 and MCM9 knock out mice 18:10 - 18:25 (15min) Tissue specific replication defects and their different outcome in MCM8 and MCM9 knock out mice Malik Lutzmann (short talk 1) Dîner 19:30 - 21:30 (2h) Dîner	ASXL1 mutations induce an MSD-like disease in mice via derepression of HoxA9 and miR125a 8:30 - 8:50 (20min) ASXL1 mutations induce an MSD-like disease in mice via derepression of HoxA9 and miR125a Toshio Kitamura The H3.3 histone chaperone HIRA primes chromatin for transcription recovery after DNA damage 8:50 - 9:10 (20min) The H3.3 histone chaperone HIRA primes chromatin for transcription recovery after DNA damage Geneviève Almouzni Genomic imprinting in mammals: ‘imprinting control regions’ mediate mono-allelic expression at endogenous and ectopic gene loci 9:10 - 9:30 (20min) Genomic imprinting in mammals: ‘imprinting control regions’ mediate mono-allelic expression at endogenous and ectopic gene loci Robert Feil Ubiquitylation/deubiquitylation circuit of histone H3 at K23 couples maintenance DNA methylation with DNA 9:30 - 9:50 (20min) Ubiquitylation/deubiquitylation circuit of histone H3 at K23 couples maintenance DNA methylation with DNA Makoto Nakanishi A small molecule, agonist of aldosterone, sensitizes cancer cells to platinum derived treatment through the degradation of the XPB helicase of TFIIH 9:50 - 10:10 (20min) A small molecule, agonist of aldosterone, sensitizes cancer cells to platinum derived treatment through the degradation of the XPB helicase of TFIIH Frédéric Coin Pause café 10:15 - 10:45 (30min) Pause café When splicing meets splicing 10:45 - 11:05 (20min) When splicing meets splicing Annick Harel-Bellan Polycomb proteins in Drosophila development and cancer 11:05 - 11:25 (20min) Polycomb proteins in Drosophila development and cancer Giacomo Cavalli Breast cancer risks in germline BRCA1 mutations carrier women 11:25 - 11:45 (20min) Breast cancer risks in germline BRCA1 mutations carrier women Jean Feunteun Molecular links between microenvironmental signals and epigenetic reprogramming processes via long non-coding RNA in glioblastoma 11:45 - 12:00 (15min) Molecular links between microenvironmental signals and epigenetic reprogramming processes via long non-coding RNA in glioblastoma Yutaka Kondo (short talk 2) Tumor Suppressor FOXP3 Orchestrates H4K16ac and H3K4me3 for Target Gene Activation in Breast Cancer Cells 12:00 - 12:15 (15min) Tumor Suppressor FOXP3 Orchestrates H4K16ac and H3K4me3 for Target Gene Activation in Breast Cancer Cells Hiroto Katoh (short talk 3) Déjeuner 12:30 - 13:45 (1h15) Déjeuner What is the Warburg effect ? Next-generation proteomics uncovers the secret of cancer. 14:00 - 14:20 (20min) What is the Warburg effect ? Next-generation proteomics uncovers the secret of cancer. Keiichi Nakayama Characterization of a Mink1-Prickle pathway implicated in cancer cell migration 14:20 - 14:40 (20min) Characterization of a Mink1-Prickle pathway implicated in cancer cell migration Avais Daulat Coordinated Controls of checkpoints and metabolism by the transcription factor E4F1: Toward novel synthetic lethal approaches to cancer vulnerabilities? 14:40 - 15:00 (20min) Coordinated Controls of checkpoints and metabolism by the transcription factor E4F1: Toward novel synthetic lethal approaches to cancer vulnerabilities? Claude Sardet Hypoxia and nutrient starvation induce tumor aggressiveness 15:00 - 15:15 (15min) Hypoxia and nutrient starvation induce tumor aggressiveness Tsuyoshi Osawa (short talk 4) Elucidation of the roles of membrane lipids in the progression of epithelial-mesenchymal transition 15:15 - 15:30 (15min) Elucidation of the roles of membrane lipids in the progression of epithelial-mesenchymal transition Junichi Ikenouchi (short talk 5) Pause café 15:30 - 16:00 (30min) Pause café Molecular mechanisms of osteoclastogenic signal 16:00 - 16:20 (20min) Molecular mechanisms of osteoclastogenic signal Jun-Ichiro Inoue Study of mechanical stress and tumor cell proliferation in multi-cellular tumor spheroid 16:20 - 16:40 (20min) Study of mechanical stress and tumor cell proliferation in multi-cellular tumor spheroid Valérie Lobjois Loss of E-cadherin in the liver leads to sclerosing cholangitis and promotes tumorigenesis in mice 16:40 - 17:00 (20min) Loss of E-cadherin in the liver leads to sclerosing cholangitis and promotes tumorigenesis in mice Shin Maeda Cyclin A2: a novel player in cell-cell and cell-niche interactions 17:00 - 17:20 (20min) Cyclin A2: a novel player in cell-cell and cell-niche interactions Jean-Marie Blanchard Cullin3 E3 ubiquitin ligase-based angiogenic regulation 17:20 - 17:40 (20min) Cullin3 E3 ubiquitin ligase-based angiogenic regulation Shigeki Higahsiyama Biochemical and biophysical analysis for the H. pylori CagA-SHP2 oncoprotein interaction 17:40 - 17:55 (15min) Biochemical and biophysical analysis for the H. pylori CagA-SHP2 oncoprotein interaction Takeru Hayashi (short talk 6) Réception par le Maire de Toulouse 18:30 - 19:30 (1h) Réception par le Maire de Toulouse Visite guidée de Toulouse la nuit 19:30 - 21:00 (1h30) Visite guidée de Toulouse la nuit Dîner 21:00 - 23:00 (2h) Dîner	HTLV-1 bZIP factor determines cell tropism 8:30 - 8:50 (20min) HTLV-1 bZIP factor determines cell tropism Masao Matsuoka Cell polarity, cell signaling and cancer 8:50 - 9:10 (20min) Cell polarity, cell signaling and cancer Jean-Paul Borg Mechanisms determining subcellular localization of the oncogenic protein tyosinase phosphatase SHP2 9:10 - 9:30 (20min) Mechanisms determining subcellular localization of the oncogenic protein tyosinase phosphatase SHP2 Masanori Hatakeyama TTF-1/NKX2-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma 9:30 - 9:45 (15min) TTF-1/NKX2-1-induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma Tomoya Yamaguchi (short talk 7) Novel functions of Wnt signaling pathways in mitotic progression. 9:45 - 10:00 (15min) Novel functions of Wnt signaling pathways in mitotic progression. Koji Kikuchi (short talk 8) Pause café 10:00 - 10:30 (30min) Pause café Mechanisms of development in childhood cancers, translational perspectives 10:30 - 10:50 (20min) Mechanisms of development in childhood cancers, translational perspectives Olivier Delatre Oncogenic role of the retina-specific transcription factor NRL in metastatic medulloblastoma 10:50 - 11:05 (15min) Oncogenic role of the retina-specific transcription factor NRL in metastatic medulloblastoma Célio Pouponnot (short talk 9) Specific roles for BRAF and CRAF in NRAS-induced mouse melanoma 11:05 - 11:25 (20min) Specific roles for BRAF and CRAF in NRAS-induced mouse melanoma Alain Eychène Contribution of Keap1-Nrf2 pathway to metabolic reprogramming and cell proliferation 11:25 - 11:40 (15min) Contribution of Keap1-Nrf2 pathway to metabolic reprogramming and cell proliferation Hozumi Motohashi (short talk 10) Déjeuner 12:00 - 13:30 (1h30) Déjeuner Tour de l'Oncopole, Visite de Carcassonne.. et vin rouge! 14:00 - 20:00 (6h) Tour de l'Oncopole, Visite de Carcassonne.. et vin rouge! Dîner 21:00 - 23:00 (2h) Dîner	CD44s-xCT axis is a therapeutic target for cancer stem cells 8:30 - 8:50 (20min) CD44s-xCT axis is a therapeutic target for cancer stem cells Hideyuki Saya Function of thrombopoietin receptor (MPL) mutations in hematological myeloid malignancies 8:50 - 9:10 (20min) Function of thrombopoietin receptor (MPL) mutations in hematological myeloid malignancies William Vainchenker or Isabelle Plo The calcineurin/NFAT pathway in leukemia and breast cancer models 9:10 - 9:30 (20min) The calcineurin/NFAT pathway in leukemia and breast cancer models Christine Tran Quang Genetic analysis of Down Syndrome-related myeloid neoplasms 9:30 - 9:50 (20min) Genetic analysis of Down Syndrome-related myeloid neoplasms Seishi Ogawa Tumor HEVs: specialized blood vessels which contribute to the fight against cancer 9:50 - 10:10 (20min) Tumor HEVs: specialized blood vessels which contribute to the fight against cancer Jean-Philippe Girard Pause café 10:15 - 10:45 (30min) Pause café Leukemic gene network: from genetic interaction to in vivo function 10:45 - 11:05 (20min) Leukemic gene network: from genetic interaction to in vivo function Takuro Nakamura Activation of distinct oncogenic signaling pathways in human mammary epithelial cells results in fully different cascades of genetic and epigenetic modifications 11:05 - 11:25 (20min) Activation of distinct oncogenic signaling pathways in human mammary epithelial cells results in fully different cascades of genetic and epigenetic modifications Charles Theillet Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence 11:25 - 11:40 (15min) Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence Shoichiro Takeishi (short talk 11) Small nucleolar RNAs and long non coding RNAs: new players in hematological cancers 11:40 - 12:00 (20min) Small nucleolar RNAs and long non coding RNAs: new players in hematological cancers Pierre Brousset PML, an essential contributor of APL response to targeted therapies 12:00 - 12:20 (20min) PML, an essential contributor of APL response to targeted therapies Hugues de Thé Conclusions - Fin du congrès 12:30 - 13:00 (30min) Conclusions - Fin du congrès Discours de fin

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